Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines.
Identifieur interne : 002291 ( Main/Exploration ); précédent : 002290; suivant : 002292Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines.
Auteurs : Shiming Li [États-Unis] ; Min-Hsiung Pan ; Ching-Shu Lai ; Chih-Yu Lo ; Slavik Dushenkov ; Chi-Tang HoSource :
- Bioorganic & medicinal chemistry [ 0968-0896 ] ; 2007.
English descriptors
- KwdEn :
- Anticarcinogenic Agents (chemical synthesis), Anticarcinogenic Agents (pharmacology), Antineoplastic Agents, Phytogenic (chemical synthesis), Antineoplastic Agents, Phytogenic (isolation & purification), Antineoplastic Agents, Phytogenic (pharmacology), Apoptosis (drug effects), Cell Proliferation (drug effects), Chromatography, High Pressure Liquid, Citrus (chemistry), Flavones (isolation & purification), Flavones (physiology), Fruit (chemistry), HL-60 Cells, Humans, Hydroxylation, Indicators and Reagents, Magnetic Resonance Spectroscopy, Plant Extracts (chemistry), Spectrometry, Mass, Electrospray Ionization, Spectrophotometry, Ultraviolet.
- MESH :
- chemical , chemical synthesis : Anticarcinogenic Agents, Antineoplastic Agents, Phytogenic.
- chemical , chemistry : Plant Extracts.
- chemical , isolation & purification : Antineoplastic Agents, Phytogenic, Flavones.
- chemical , pharmacology : Anticarcinogenic Agents, Antineoplastic Agents, Phytogenic.
- chemistry : Citrus, Fruit.
- drug effects : Apoptosis, Cell Proliferation.
- chemical , physiology : Flavones.
- Chromatography, High Pressure Liquid, HL-60 Cells, Humans, Hydroxylation, Indicators and Reagents, Magnetic Resonance Spectroscopy, Spectrometry, Mass, Electrospray Ionization, Spectrophotometry, Ultraviolet.
Abstract
Fifteen polymethoxyflavones (PMFs) and hydroxylated PMFs were isolated from sweet orange (Citrus sinensis) peel extract and synthesized to investigate their biological activity. All obtained compounds were tested in HL-60 cancer cell proliferation and apoptosis induction assays. While some PMFs and hydroxylated PMFs had moderate anti-carcinogenic activities, 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone and 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone showed strong inhibitory activities against the proliferation and induced apoptosis of HL-60 cell lines.
DOI: 10.1016/j.bmc.2007.03.021
PubMed: 17391969
Affiliations:
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Le document en format XML
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Pan</name></author><author><name sortKey="Lai, Ching Shu" sort="Lai, Ching Shu" uniqKey="Lai C" first="Ching-Shu" last="Lai">Ching-Shu Lai</name></author><author><name sortKey="Lo, Chih Yu" sort="Lo, Chih Yu" uniqKey="Lo C" first="Chih-Yu" last="Lo">Chih-Yu Lo</name></author><author><name sortKey="Dushenkov, Slavik" sort="Dushenkov, Slavik" uniqKey="Dushenkov S" first="Slavik" last="Dushenkov">Slavik Dushenkov</name></author><author><name sortKey="Ho, Chi Tang" sort="Ho, Chi Tang" uniqKey="Ho C" first="Chi-Tang" last="Ho">Chi-Tang Ho</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:17391969</idno><idno type="pmid">17391969</idno><idno type="doi">10.1016/j.bmc.2007.03.021</idno><idno type="wicri:Area/PubMed/Corpus">000B32</idno><idno type="wicri:Area/PubMed/Curation">000B32</idno><idno type="wicri:Area/PubMed/Checkpoint">000B32</idno><idno type="wicri:Area/Ncbi/Merge">000689</idno><idno 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08901-8520</wicri:regionArea><placeName><region type="state">New Jersey</region><settlement type="city">New Brunswick (New Jersey)</settlement></placeName><orgName type="university">Université Rutgers</orgName></affiliation></author><author><name sortKey="Pan, Min Hsiung" sort="Pan, Min Hsiung" uniqKey="Pan M" first="Min-Hsiung" last="Pan">Min-Hsiung Pan</name></author><author><name sortKey="Lai, Ching Shu" sort="Lai, Ching Shu" uniqKey="Lai C" first="Ching-Shu" last="Lai">Ching-Shu Lai</name></author><author><name sortKey="Lo, Chih Yu" sort="Lo, Chih Yu" uniqKey="Lo C" first="Chih-Yu" last="Lo">Chih-Yu Lo</name></author><author><name sortKey="Dushenkov, Slavik" sort="Dushenkov, Slavik" uniqKey="Dushenkov S" first="Slavik" last="Dushenkov">Slavik Dushenkov</name></author><author><name sortKey="Ho, Chi Tang" sort="Ho, Chi Tang" uniqKey="Ho C" first="Chi-Tang" last="Ho">Chi-Tang Ho</name></author></analytic><series><title level="j">Bioorganic & medicinal chemistry</title><idno type="ISSN">0968-0896</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anticarcinogenic Agents (chemical synthesis)</term><term>Anticarcinogenic Agents (pharmacology)</term><term>Antineoplastic Agents, Phytogenic (chemical synthesis)</term><term>Antineoplastic Agents, Phytogenic (isolation & purification)</term><term>Antineoplastic Agents, Phytogenic (pharmacology)</term><term>Apoptosis (drug effects)</term><term>Cell Proliferation (drug effects)</term><term>Chromatography, High Pressure Liquid</term><term>Citrus (chemistry)</term><term>Flavones (isolation & purification)</term><term>Flavones (physiology)</term><term>Fruit (chemistry)</term><term>HL-60 Cells</term><term>Humans</term><term>Hydroxylation</term><term>Indicators and Reagents</term><term>Magnetic Resonance Spectroscopy</term><term>Plant Extracts (chemistry)</term><term>Spectrometry, Mass, Electrospray Ionization</term><term>Spectrophotometry, Ultraviolet</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Anticarcinogenic Agents</term><term>Antineoplastic Agents, Phytogenic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antineoplastic Agents, Phytogenic</term><term>Flavones</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anticarcinogenic Agents</term><term>Antineoplastic Agents, Phytogenic</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus</term><term>Fruit</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term><term>Cell Proliferation</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Flavones</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Chromatography, High Pressure Liquid</term><term>HL-60 Cells</term><term>Humans</term><term>Hydroxylation</term><term>Indicators and Reagents</term><term>Magnetic Resonance Spectroscopy</term><term>Spectrometry, Mass, Electrospray Ionization</term><term>Spectrophotometry, Ultraviolet</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Fifteen polymethoxyflavones (PMFs) and hydroxylated PMFs were isolated from sweet orange (Citrus sinensis) peel extract and synthesized to investigate their biological activity. All obtained compounds were tested in HL-60 cancer cell proliferation and apoptosis induction assays. While some PMFs and hydroxylated PMFs had moderate anti-carcinogenic activities, 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone and 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone showed strong inhibitory activities against the proliferation and induced apoptosis of HL-60 cell lines.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>New Jersey</li></region><settlement><li>New Brunswick (New Jersey)</li></settlement><orgName><li>Université Rutgers</li></orgName></list><tree><noCountry><name sortKey="Dushenkov, Slavik" sort="Dushenkov, Slavik" uniqKey="Dushenkov S" first="Slavik" last="Dushenkov">Slavik Dushenkov</name><name sortKey="Ho, Chi Tang" sort="Ho, Chi Tang" uniqKey="Ho C" first="Chi-Tang" last="Ho">Chi-Tang Ho</name><name sortKey="Lai, Ching Shu" sort="Lai, Ching Shu" uniqKey="Lai C" first="Ching-Shu" last="Lai">Ching-Shu Lai</name><name sortKey="Lo, Chih Yu" sort="Lo, Chih Yu" uniqKey="Lo C" first="Chih-Yu" last="Lo">Chih-Yu Lo</name><name sortKey="Pan, Min Hsiung" sort="Pan, Min Hsiung" uniqKey="Pan M" first="Min-Hsiung" last="Pan">Min-Hsiung Pan</name></noCountry><country name="États-Unis"><region name="New Jersey"><name sortKey="Li, Shiming" sort="Li, Shiming" uniqKey="Li S" first="Shiming" last="Li">Shiming Li</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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